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Because this paper is fully open-access and reports the exact functional forms, geometry, loading protocol, and parameter values for a small (~480-bead) LAMMPS model, re-running the simulation to verify that the H-bond unfolding plateau creates large dissipative yield regions is straightforward. For real biological intermediate filament networks, published rheology and cell-stretching studies confirm extreme extensibility, but do not directly resolve nanoscale unfolding zones around engineered flaws without confounding from filament sliding. The claim is therefore fully testable in the stated model and partially testable for biological networks.
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Proposed test with existing data: Re-implement the 20-by-24 bead square alpha-helix network in LAMMPS using the four-regime piecewise-harmonic bond potential and harmonic bending potential specified in the open-access paper, and compare failure strain and yield-zone size around a central flaw against a control network lacking the H-bond unfolding plateau. Confirmation requires large unfolding yield regions around the flaw and failure strains above 100% that vanish when the unfolding plateau is removed.
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Direct nanoscale experimental maps of unfolding yield zones around defined cracks in biological intermediate filament networks are scarce.
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The mesoscale model represents each filament as a single alpha-helix on a regular square lattice and omits inter-filament sliding present in real intermediate filament tetramers.
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open-access specification of the coarse-grained equations, system geometry, boundary conditions, and piecewise spring parameters
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Candidate dataset: Ackbarow et al. 2009 PLoS ONE Full Text and Parameter Table
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Candidate dataset: LAMMPS Molecular Dynamics Simulator
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Gemini 4 Argon
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Gemini 4 Argon on buehler-2009-helical-networks-01: partially-resolvable, resolvability 0.67
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http://purl.org/nanopub/x/hasPublicKey
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https://w3id.org/np/RAqdvfnKmxJKYUP_tPh0xXBpsuNezBoTU1nfCDV27d-Vc/sig
http://purl.org/nanopub/x/hasSignature
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https://w3id.org/np/RAqdvfnKmxJKYUP_tPh0xXBpsuNezBoTU1nfCDV27d-Vc/sig
http://purl.org/nanopub/x/hasSignatureTarget
https://w3id.org/np/RAqdvfnKmxJKYUP_tPh0xXBpsuNezBoTU1nfCDV27d-Vc
https://w3id.org/np/RAqdvfnKmxJKYUP_tPh0xXBpsuNezBoTU1nfCDV27d-Vc/sig
http://purl.org/nanopub/x/signedBy
https://orcid.org/0009-0007-4948-9192