https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w/Head https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w http://www.nanopub.org/nschema#hasAssertion https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w/assertion https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w http://www.nanopub.org/nschema#hasProvenance https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w/provenance https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w http://www.nanopub.org/nschema#hasPublicationInfo https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w/pubinfo https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w/assertion https://w3id.org/delphi/resource/claim/buehler-2009-angiogenesis-03 http://purl.org/dc/terms/description A single mechanical cue, cyclic tensile strain, can trigger a cascade of autocrine and paracrine signalling events between endothelial and smooth muscle cells that is critical to angiogenesis. https://w3id.org/delphi/resource/claim/buehler-2009-angiogenesis-03 http://purl.org/dc/terms/type mechanism https://w3id.org/delphi/resource/claim/buehler-2009-angiogenesis-03 http://www.w3.org/1999/02/22-rdf-syntax-ns#type https://w3id.org/delphi/ontology/Claim https://w3id.org/delphi/resource/claim/buehler-2009-angiogenesis-03 http://www.w3.org/2000/01/rdf-schema#label A single mechanical cue triggers an autocrine and paracrine signalling cascade https://w3id.org/delphi/resource/claim/buehler-2009-angiogenesis-03 https://w3id.org/delphi/ontology/context Yu Ching Yung et al., “Cyclic tensile strain triggers a sequence of autocrine and paracrine signaling to regulate angiogenic sprouting in human vascular cells”, Proceedings of the National Academy of Sciences 106, 15279-15284 (2009), doi:10.1073/pnas.0905891106; Abstract. Scope: In vitro model of early angiogenesis https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w/provenance https://doi.org/10.1073/pnas.0905891106 http://purl.org/dc/terms/bibliographicCitation Yu Ching Yung, Jeiwook Chae, Markus J. Buehler, Craig P. Hunter, David J. Mooney. Cyclic tensile strain triggers a sequence of autocrine and paracrine signaling to regulate angiogenic sprouting in human vascular cells. Proceedings of the National Academy of Sciences 106, 15279-15284 (2009). doi:10.1073/pnas.0905891106 https://doi.org/10.1073/pnas.0905891106 http://purl.org/dc/terms/creator Yu Ching Yung, Jeiwook Chae, Markus J. Buehler, Craig P. Hunter, David J. 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Checked by build/check.py. https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w/quote http://www.w3.org/ns/prov#hadPrimarySource https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI:10.1073/pnas.0905891106&resultType=core&format=json https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w/quote http://www.w3.org/ns/prov#wasQuotedFrom https://doi.org/10.1073/pnas.0905891106 https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w/quote https://schema.org/text These results demonstrate that a singular mechanical cue (cyclic tensile strain) can trigger a cascade of autocrine and paracrine signaling events between ECs and SMCs critical to the angiogenic process. https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w/sourceChecksum http://spdx.org/rdf/terms#algorithm http://spdx.org/rdf/terms#checksumAlgorithm_sha256 https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w/sourceChecksum http://spdx.org/rdf/terms#checksumValue a9912c839d3da8e9872e3ae20abe855f3ab1a6790a8ce7381466b7561048c712 https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w/sourceChecksum http://www.w3.org/2000/01/rdf-schema#comment Checksum of the vendored text file inputs/2009-angiogenesis.abstract.txt, not of the publisher's copy. https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI:10.1073/pnas.0905891106&resultType=core&format=json http://spdx.org/rdf/terms#checksum https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w/sourceChecksum https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI:10.1073/pnas.0905891106&resultType=core&format=json http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/ns/prov#Entity https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI:10.1073/pnas.0905891106&resultType=core&format=json http://www.w3.org/2000/01/rdf-schema#label Abstract of Cyclic tensile strain triggers a sequence of autocrine and paracrine signaling to regulate angiogenic sprouting in human vascular cells, as read https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI:10.1073/pnas.0905891106&resultType=core&format=json https://schema.org/about https://doi.org/10.1073/pnas.0905891106 https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w/pubinfo https://w3id.org/delphi/resource/domain/buehler-protein-materials http://www.w3.org/2000/01/rdf-schema#label buehler-protein-materials https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w http://purl.org/dc/terms/created 2026-11-08T04:38:11.893Z https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w http://purl.org/dc/terms/creator https://orcid.org/0009-0007-4948-9192 https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w http://purl.org/dc/terms/license https://creativecommons.org/licenses/by/4.0/ https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w http://purl.org/nanopub/x/hasNanopubType https://w3id.org/delphi/ontology/Claim https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w http://purl.org/nanopub/x/introduces https://w3id.org/delphi/resource/claim/buehler-2009-angiogenesis-03 https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w http://www.w3.org/2000/01/rdf-schema#label Yu Ching Yung et al. 2009 claim: A single mechanical cue triggers an autocrine and paracrine signalling cascade https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w https://w3id.org/delphi/ontology/domain https://w3id.org/delphi/resource/domain/buehler-protein-materials https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w/sig http://purl.org/nanopub/x/hasAlgorithm RSA https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w/sig http://purl.org/nanopub/x/hasPublicKey MIIBIjANBgkqhkiG9w0BAQEFAAOCAQ8AMIIBCgKCAQEAyFHtPB6p0mCjDozxlOY9CmO3nBm7Te3jFbXyLmM+G1tGe47Da0jYIbhkl9Oo1ZjxmCa3LCwlEqK8gj6hEIcL4ahW30JXh9HycfKVk1bugkzMEV15tJdTzAU3sGMFnbNsn43xY2LFLy45tApkRm5byEiM7oRRrooIdwoQKnP4Wzq/bfAoJ9qvW+MGkelyOTd1jbSt+KfmT7xKmDfWzAHddUlWwMX2QJOLxDaffOteTop6ZRgPiNmPJKA/S62Gac9XtSYT3oDkZ6/nr5cxxNLpOyxTf5FPISiCe11xYO/unYjY+mwnOfA8yhJIyx1l0O9I0vpOpn+E5TvyHJV+oSTrvwIDAQAB https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w/sig http://purl.org/nanopub/x/hasSignature Xa6n0TZ499t9+IsuPNNYMZPUeDXXtc8UdQWpclfYUmfa4rwjgyTBh9Gu+MG22bwOpqmbCKZQRpg6LAMu1eO8JGyDnHY1aEQJwVQ0ONa7kkJigyqGabvFLeIXPZJ5jHfvlXgsXF6DWLe/aLEyi1vTSnQAxsnjFKhsYJQkLF9wuec6XiNnh5qXje9UDLebQzYMstAn3KdmUCibGnLNiWCMI0utNS5OsrTrwlCj9TE3X6ikc3G5oFC1vteyljIDpKrnNYAnphlaLUW97jk83Ky/62fUO/QvnTuAS5gv9jmc8SOMNjhTxxQRSHuFqKOTQ13+H4hTYX5pJaIyN0xjSoVV0g== https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w/sig http://purl.org/nanopub/x/hasSignatureTarget https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w https://w3id.org/np/RAeqI5P89lsIWoCQX8bbPgG5Tw94LGOhdhUf4bclNOd-w/sig http://purl.org/nanopub/x/signedBy https://orcid.org/0009-0007-4948-9192