@prefix this: <https://w3id.org/np/RAcco8rGC5LVXB_OHsdFJeuOHOBV8m7yOfOzEitNxqZOE> .
@prefix sub: <https://w3id.org/np/RAcco8rGC5LVXB_OHsdFJeuOHOBV8m7yOfOzEitNxqZOE/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

sub:Head {
  this: a np:Nanopublication;
    np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo .
}

sub:assertion {
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    dc:description "Parts of the proposed response can be sought in public perturbational expression data, making the claim more than purely conceptual. Those data would test only proxies for a temporally ordered autocrine-paracrine cascade and would not establish that the mechanism is critical in angiogenesis generally. The causal breadth therefore remains unresolved without additional matched perturbation data.";
    dc:subject <https://w3id.org/delphi/resource/concept/dataset-resolvability-0.2.0>;
    <http://www.w3.org/2000/01/rdf-schema#comment> "Proposed test with existing data: Use matched cyclic-strain perturbation data to reconstruct the temporal sequence of endothelial autocrine responses, smooth-muscle paracrine responses, and angiogenic phenotypes, then test whether blocking proposed mediators interrupts downstream events. Failure to observe ordered signalling or persistence after blockade would refute the specified cascade.";
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    <https://w3id.org/delphi/ontology/evidenceAgainst> "Critical to angiogenesis is broader than the in vitro model.",
      "Expression measurements alone cannot establish secretion or cell-cell causality.",
      "Matched temporal and inhibitor data may be absent.";
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    prov:wasAttributedTo <https://w3id.org/delphi/resource/agent/delphisci-resolvability-assessor-gpt-5.6-sol-medium>;
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    prov:wasAttributedTo <https://w3id.org/delphi/resource/agent/delphisci-resolvability-assessor-gpt-5.6-sol-medium>;
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  <https://w3id.org/delphi/resource/claim/buehler-2009-angiogenesis-03> <https://w3id.org/delphi/ontology/hasAssessment>
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    a <https://w3id.org/delphi/ontology/EvidenceItem>;
    dc:description "public expression studies for testing parts of the cellular response to mechanical strain";
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    prov:wasDerivedFrom <https://www.ncbi.nlm.nih.gov/geo/> .
  
  <https://w3id.org/delphi/resource/model/gpt-5.6-sol-medium> a <https://w3id.org/delphi/ontology/LanguageModel>;
    dc:identifier "gpt-5.6-sol-medium";
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}

sub:provenance {
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    prov:wasDerivedFrom <https://github.com/fractastical/delphisci/blob/67fe5b156cfeca15a2ded33e0face4177d03101c/claim-sources/buehler-protein-materials/assessment/raw/gpt/batch-4.json>,
      <https://w3id.org/delphi/resource/concept/dataset-resolvability-0.2.0>;
    prov:wasGeneratedBy sub:assessment .
  
  sub:assessment a prov:Activity;
    prov:qualifiedAssociation sub:assessmentPlan;
    prov:wasAssociatedWith <https://w3id.org/delphi/resource/agent/delphisci-resolvability-assessor-gpt-5.6-sol-medium> .
  
  sub:assessmentPlan prov:hadPlan <https://github.com/fractastical/delphisci/blob/67fe5b156cfeca15a2ded33e0face4177d03101c/claim-sources/buehler-protein-materials/README.md> .
}

sub:pubinfo {
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      "buehler-protein-materials" .
  
  this: dc:created "2026-11-08T04:48:50.317Z"^^xsd:dateTime;
    dc:creator <https://orcid.org/0009-0007-4948-9192>;
    dc:license <https://creativecommons.org/licenses/by/4.0/>;
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    npx:introduces <https://w3id.org/delphi/resource/assessment/buehler-2009-angiogenesis-03--gpt>;
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}