https://w3id.org/np/RAVL8hRFURhqGZ1WFRnZs8jpl44TPfrDgWKnizDqspo4I/Head https://w3id.org/np/RAVL8hRFURhqGZ1WFRnZs8jpl44TPfrDgWKnizDqspo4I http://www.nanopub.org/nschema#hasAssertion https://w3id.org/np/RAVL8hRFURhqGZ1WFRnZs8jpl44TPfrDgWKnizDqspo4I/assertion https://w3id.org/np/RAVL8hRFURhqGZ1WFRnZs8jpl44TPfrDgWKnizDqspo4I http://www.nanopub.org/nschema#hasProvenance https://w3id.org/np/RAVL8hRFURhqGZ1WFRnZs8jpl44TPfrDgWKnizDqspo4I/provenance https://w3id.org/np/RAVL8hRFURhqGZ1WFRnZs8jpl44TPfrDgWKnizDqspo4I http://www.nanopub.org/nschema#hasPublicationInfo https://w3id.org/np/RAVL8hRFURhqGZ1WFRnZs8jpl44TPfrDgWKnizDqspo4I/pubinfo https://w3id.org/np/RAVL8hRFURhqGZ1WFRnZs8jpl44TPfrDgWKnizDqspo4I http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication https://w3id.org/np/RAVL8hRFURhqGZ1WFRnZs8jpl44TPfrDgWKnizDqspo4I/assertion https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-17--claim-test http://purl.org/dc/terms/description Sensitization uses the authors' rule on NewDrugResSensitBreak.mat: at least two nonzero stimulus codes, all equal. The biological fraction is the number of models with at least one such pair, divided by 35. The percentage matches column 2 of their deposited percentage matrix. No random-circuit scores are deposited and none were generated. The pre-registered refute rule requires at least 20 random models, so a biological fraction alone does not close the verdict. https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-17--claim-test http://www.w3.org/1999/02/22-rdf-syntax-ns#type https://w3id.org/delphi/ontology/Assessment https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-17--claim-test http://www.w3.org/2000/01/rdf-schema#comment Measured: 0.6571428571428571 fraction of 35 models with at least one sensitizing pair (n = 35). Interpretation: Sensitization here is an ODE simulation outcome, not a measured cellular sensitization. data_kind will be computational. https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-17--claim-test http://www.w3.org/2000/01/rdf-schema#label Claim test of levin-2022-grn-learning-17: inconclusive, confidence 0.4 https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-17--claim-test http://www.w3.org/2000/01/rdf-schema#seeAlso https://github.com/fractastical/delphisci/blob/bf2af6ee0a84e23ffa6414ad7a0a50a8c276506e/test-data/claim-tests/levin-papers/levin-2022-grn-learning-17/result.json https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-17--claim-test http://www.w3.org/ns/prov#wasAttributedTo https://w3id.org/delphi/resource/agent/delphisci-claim-tester-grok-4-7 https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-17--claim-test https://w3id.org/delphi/ontology/admissibleDatasets The published ODE models fetched by BioModels id, and random circuits matched in size and scored with the same sensitization rule. A typed copy of the paper's 27 of 35 is not admissible. https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-17--claim-test https://w3id.org/delphi/ontology/assessmentType claim-test/0.1.0 https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-17--claim-test https://w3id.org/delphi/ontology/dataKind computational https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-17--claim-test https://w3id.org/delphi/ontology/disconfirmingObservation The biological fraction is below 27/35, or the median random pairing fraction is 10% or higher. https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-17--claim-test https://w3id.org/delphi/ontology/evidenceAgainst 23 of 35 models have at least one sensitizing pair. That fraction, 0.657, is below the pre-registered biological bar of 27/35. https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-17--claim-test https://w3id.org/delphi/ontology/evidenceAgainst The ODEs were not re-integrated. https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-17--claim-test https://w3id.org/delphi/ontology/evidenceAgainst Zero random circuits were scored. The pre-registered rule refutes only when at least 20 random models were tested, so the verdict is inconclusive rather than a refutation. https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-17--claim-test https://w3id.org/delphi/ontology/expectedObservation At least 27/35 of the biological models have a sensitizing stimulus-response pair, and the median random model has sensitizing pairs in under 10% of pairings. https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-17--claim-test https://w3id.org/delphi/ontology/failCriterion Refutes if the biological fraction is < 27/35, or if the random median pair-fraction is >= 0.10, provided at least 10 biological models and at least 20 random models were tested. Mixed is not used for a miss of either bar: either miss refutes the conjunction. Inconclusive with reason underpowered if fewer than 10 biological models or fewer than 20 random models are tested. Inconclusive with reason data-unavailable if the biological models cannot be fetched. https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-17--claim-test https://w3id.org/delphi/ontology/hasConfidence 0.4 https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-17--claim-test https://w3id.org/delphi/ontology/hasEvidence https://w3id.org/delphi/resource/evidence/levin-2022-grn-learning-17--claim-test--dataset-1 https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-17--claim-test https://w3id.org/delphi/ontology/hasEvidence https://w3id.org/delphi/resource/evidence/levin-2022-grn-learning-17--claim-test--dataset-2 https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-17--claim-test https://w3id.org/delphi/ontology/hasVerdict inconclusive https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-17--claim-test https://w3id.org/delphi/ontology/hypothesis Sensitization, a progressive 1.5-fold increase in response, occurs in at least 27 of 35 biological pathway models and in under 10% of stimulus-response pairings in random models. https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-17--claim-test https://w3id.org/delphi/ontology/inferenceMethod Score each stimulus-response pair for a progressive 1.5-fold increase. Biological model fraction against 27/35. Median over random models of the pair fraction against 0.10. Both are required for supports. https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-17--claim-test https://w3id.org/delphi/ontology/passCriterion Pre-registered before any model file or simulation output is downloaded. The pass bars are the fractions stated in the claim. Sensitization of a pair is a progressive increase of response amplitude to at least 1.5 times the first response across repeated stimulations. A biological model counts as sensitizing if at least one stimulus-response pair sensitizes. Supports only if (biological models that sensitize) / (biological models tested) >= 27/35 and, across random models, the median of (sensitizing pairs / pairs tested) is < 0.10. 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