https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/Head https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg http://www.nanopub.org/nschema#hasAssertion https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/assertion https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg http://www.nanopub.org/nschema#hasProvenance https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/provenance https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg http://www.nanopub.org/nschema#hasPublicationInfo https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/pubinfo https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/assertion https://w3id.org/delphi/resource/claim/buehler-2009-angiogenesis-01 http://purl.org/dc/terms/description Cyclic tensile strain of human umbilical vein endothelial cells up-regulates secretion of angiopoietin-2 and PDGF-BB and enhances endothelial migration and sprout formation; these effects disappear when endogenous Ang-2 is knocked down by shRNA. https://w3id.org/delphi/resource/claim/buehler-2009-angiogenesis-01 http://purl.org/dc/terms/type experimental-result https://w3id.org/delphi/resource/claim/buehler-2009-angiogenesis-01 http://www.w3.org/1999/02/22-rdf-syntax-ns#type https://w3id.org/delphi/ontology/Claim https://w3id.org/delphi/resource/claim/buehler-2009-angiogenesis-01 http://www.w3.org/2000/01/rdf-schema#label Cyclic strain of endothelial cells raises Ang-2 and PDGF-BB secretion and drives sprouting https://w3id.org/delphi/resource/claim/buehler-2009-angiogenesis-01 https://w3id.org/delphi/ontology/context Yu Ching Yung et al., “Cyclic tensile strain triggers a sequence of autocrine and paracrine signaling to regulate angiogenic sprouting in human vascular cells”, Proceedings of the National Academy of Sciences 106, 15279-15284 (2009), doi:10.1073/pnas.0905891106; Abstract. Scope: HUVECs under cyclic tensile strain in vitro https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/provenance https://doi.org/10.1073/pnas.0905891106 http://purl.org/dc/terms/bibliographicCitation Yu Ching Yung, Jeiwook Chae, Markus J. Buehler, Craig P. Hunter, David J. Mooney. Cyclic tensile strain triggers a sequence of autocrine and paracrine signaling to regulate angiogenic sprouting in human vascular cells. Proceedings of the National Academy of Sciences 106, 15279-15284 (2009). doi:10.1073/pnas.0905891106 https://doi.org/10.1073/pnas.0905891106 http://purl.org/dc/terms/creator Yu Ching Yung, Jeiwook Chae, Markus J. Buehler, Craig P. Hunter, David J. Mooney https://doi.org/10.1073/pnas.0905891106 http://purl.org/dc/terms/date 2009 https://doi.org/10.1073/pnas.0905891106 http://purl.org/dc/terms/identifier PMC2741242 https://doi.org/10.1073/pnas.0905891106 http://purl.org/dc/terms/identifier doi:10.1073/pnas.0905891106 https://doi.org/10.1073/pnas.0905891106 http://purl.org/dc/terms/identifier pmid:19706407 https://doi.org/10.1073/pnas.0905891106 http://purl.org/dc/terms/title Cyclic tensile strain triggers a sequence of autocrine and paracrine signaling to regulate angiogenic sprouting in human vascular cells https://doi.org/10.1073/pnas.0905891106 http://www.w3.org/1999/02/22-rdf-syntax-ns#type https://schema.org/CreativeWork https://w3id.org/delphi/resource/agent/delphisci-buehler-protein-materials-extractor http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/ns/prov#SoftwareAgent https://w3id.org/delphi/resource/agent/delphisci-buehler-protein-materials-extractor http://www.w3.org/2000/01/rdf-schema#label delphisci buehler-protein-materials claim extractor https://w3id.org/delphi/resource/agent/delphisci-buehler-protein-materials-extractor http://www.w3.org/ns/prov#actedOnBehalfOf https://orcid.org/0009-0007-4948-9192 https://w3id.org/delphi/resource/agent/delphisci-buehler-protein-materials-extractor https://w3id.org/delphi/ontology/usesModel https://w3id.org/delphi/resource/model/claude-fable-5.1 https://w3id.org/delphi/resource/model/claude-fable-5.1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type https://w3id.org/delphi/ontology/LanguageModel https://w3id.org/delphi/resource/model/claude-fable-5.1 http://www.w3.org/2000/01/rdf-schema#label Claude Fable 5.1 https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/assertion http://www.w3.org/ns/prov#wasAttributedTo https://w3id.org/delphi/resource/agent/delphisci-buehler-protein-materials-extractor https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/assertion http://www.w3.org/ns/prov#wasDerivedFrom https://doi.org/10.1073/pnas.0905891106 https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/assertion http://www.w3.org/ns/prov#wasDerivedFrom https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/quote https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/assertion http://www.w3.org/ns/prov#wasGeneratedBy https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/extraction https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/extraction http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/ns/prov#Activity https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/extraction http://www.w3.org/ns/prov#qualifiedAssociation https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/extractionPlan https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/extraction http://www.w3.org/ns/prov#used https://github.com/fractastical/delphisci/blob/b89a0890bee05ef18f8202387085854fac3ca776/claim-sources/buehler-protein-materials/inputs/sources.json https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/extraction http://www.w3.org/ns/prov#used https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI:10.1073/pnas.0905891106&resultType=core&format=json https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/extraction http://www.w3.org/ns/prov#wasAssociatedWith https://w3id.org/delphi/resource/agent/delphisci-buehler-protein-materials-extractor https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/extractionPlan http://www.w3.org/ns/prov#hadPlan https://github.com/fractastical/delphisci/blob/b89a0890bee05ef18f8202387085854fac3ca776/claim-sources/buehler-protein-materials/build/generate.mjs https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/quote http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/ns/prov#Entity https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/quote http://www.w3.org/2000/01/rdf-schema#comment Quoted from the published abstract as returned by Europe PMC (2009-angiogenesis.abstract.txt, sha256 a9912c839d3da8e9872e3ae20abe855f3ab1a6790a8ce7381466b7561048c712); the full text was not read (not in Europe PMC open-access subset). Checked by build/check.py. https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/quote http://www.w3.org/ns/prov#hadPrimarySource https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI:10.1073/pnas.0905891106&resultType=core&format=json https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/quote http://www.w3.org/ns/prov#wasQuotedFrom https://doi.org/10.1073/pnas.0905891106 https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/quote https://schema.org/text Cyclic strain of human umbilical vein (HUV)ECs up-regulated the secretion of angiopoietin (Ang)-2 and PDGF-betabeta, and enhanced endothelial migration and sprout formation, whereas effects were eliminated with shRNA knockdown of endogenous Ang-2. https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/sourceChecksum http://spdx.org/rdf/terms#algorithm http://spdx.org/rdf/terms#checksumAlgorithm_sha256 https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/sourceChecksum http://spdx.org/rdf/terms#checksumValue a9912c839d3da8e9872e3ae20abe855f3ab1a6790a8ce7381466b7561048c712 https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/sourceChecksum http://www.w3.org/2000/01/rdf-schema#comment Checksum of the vendored text file inputs/2009-angiogenesis.abstract.txt, not of the publisher's copy. https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI:10.1073/pnas.0905891106&resultType=core&format=json http://spdx.org/rdf/terms#checksum https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/sourceChecksum https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI:10.1073/pnas.0905891106&resultType=core&format=json http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/ns/prov#Entity https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI:10.1073/pnas.0905891106&resultType=core&format=json http://www.w3.org/2000/01/rdf-schema#label Abstract of Cyclic tensile strain triggers a sequence of autocrine and paracrine signaling to regulate angiogenic sprouting in human vascular cells, as read https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI:10.1073/pnas.0905891106&resultType=core&format=json https://schema.org/about https://doi.org/10.1073/pnas.0905891106 https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/pubinfo https://w3id.org/delphi/resource/domain/buehler-protein-materials http://www.w3.org/2000/01/rdf-schema#label buehler-protein-materials https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg http://purl.org/dc/terms/created 2026-11-08T04:38:11.893Z https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg http://purl.org/dc/terms/creator https://orcid.org/0009-0007-4948-9192 https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg http://purl.org/dc/terms/license https://creativecommons.org/licenses/by/4.0/ https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg http://purl.org/nanopub/x/hasNanopubType https://w3id.org/delphi/ontology/Claim https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg http://purl.org/nanopub/x/introduces https://w3id.org/delphi/resource/claim/buehler-2009-angiogenesis-01 https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg http://www.w3.org/2000/01/rdf-schema#label Yu Ching Yung et al. 2009 claim: Cyclic strain of endothelial cells raises Ang-2 and PDGF-BB secretion and drives sprouting https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg https://w3id.org/delphi/ontology/domain https://w3id.org/delphi/resource/domain/buehler-protein-materials https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/sig http://purl.org/nanopub/x/hasAlgorithm RSA https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/sig http://purl.org/nanopub/x/hasPublicKey MIIBIjANBgkqhkiG9w0BAQEFAAOCAQ8AMIIBCgKCAQEAyFHtPB6p0mCjDozxlOY9CmO3nBm7Te3jFbXyLmM+G1tGe47Da0jYIbhkl9Oo1ZjxmCa3LCwlEqK8gj6hEIcL4ahW30JXh9HycfKVk1bugkzMEV15tJdTzAU3sGMFnbNsn43xY2LFLy45tApkRm5byEiM7oRRrooIdwoQKnP4Wzq/bfAoJ9qvW+MGkelyOTd1jbSt+KfmT7xKmDfWzAHddUlWwMX2QJOLxDaffOteTop6ZRgPiNmPJKA/S62Gac9XtSYT3oDkZ6/nr5cxxNLpOyxTf5FPISiCe11xYO/unYjY+mwnOfA8yhJIyx1l0O9I0vpOpn+E5TvyHJV+oSTrvwIDAQAB https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/sig http://purl.org/nanopub/x/hasSignature W0l5w/nq3aRUZQGe+7DK1Yuff7LBRAgxXmkYK4EYP3NJwdnketHZHuMm0O3gOlj8KIdXatNtShmIVK4WGFPA42AGUBR3ZSIBY1Aavs86Ecwgj8GoKmx2slTIe8pYlGouIySys/8S7NNGLFR+IXA8bCQLXRUclEgXKWlqxyr9+2SgKQ8yh1DkZcdMvcdvd4zG0fDlL3DprbO7cvjON3QXPEKHYtFCNM16b9XUMHqvy4x2tWHi41Oi0Ta/BlLfoEDkyw8wPDDril1K/pQGbGMOfxsO/C+7+lmuNANybnixNy+58BpklE5HZlpK9kzZaDC/RzAZTAn89PhyLWycJQ55VA== https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/sig http://purl.org/nanopub/x/hasSignatureTarget https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg https://w3id.org/np/RAN4HshF7UCqlN4cgQVOpsNhVRpTe9PwQPxCyGMvBOcIg/sig http://purl.org/nanopub/x/signedBy https://orcid.org/0009-0007-4948-9192