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Because softer motifs deform more than stiffer ones, deformation along a tropocollagen molecule is highly inhomogeneous, which can produce strain and stress concentrations within collagen fibrils; this is confirmed by stretching a segment with the physiological human type I sequence.
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Tropocollagen deforms inhomogeneously along its length
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Sebastien G. M. Uzel et al., “Nanomechanical sequencing of collagen: tropocollagen features heterogeneous elastic properties at the nanoscale”, Integrative Biology 1, 452-459 (2009), doi:10.1039/b906864c; Abstract. Scope: Human type I tropocollagen
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Sebastien G. M. Uzel, Markus J. Buehler. Nanomechanical sequencing of collagen: tropocollagen features heterogeneous elastic properties at the nanoscale. Integrative Biology 1, 452-459 (2009). doi:10.1039/b906864c
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Nanomechanical sequencing of collagen: tropocollagen features heterogeneous elastic properties at the nanoscale
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The most important implication of our results is that deformation in tropocollagen molecules is highly inhomogeneous, since softer regions deform more than stiffer regions, potentially leading to strain and stress concentrations within collagen fibrils.
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Abstract of Nanomechanical sequencing of collagen: tropocollagen features heterogeneous elastic properties at the nanoscale, as read
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