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Buehler et al., “Deformation and failure of protein materials in physiologically extreme conditions and disease”, Nature Materials 8, 175-188 (2009), doi:10.1038/nmat2387; Abstract. Scope: Protein materials in physiologically extreme conditions and disease (review) https://w3id.org/np/RAKBr9upCYheG0b3_xNqH20Rf5Ie7wuhounAfxr3qV5VI/provenance https://doi.org/10.1038/nmat2387 http://purl.org/dc/terms/bibliographicCitation Markus J. Buehler, Yu Ching Yung. Deformation and failure of protein materials in physiologically extreme conditions and disease. Nature Materials 8, 175-188 (2009). doi:10.1038/nmat2387 https://doi.org/10.1038/nmat2387 http://purl.org/dc/terms/creator Markus J. 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Checked by build/check.py. https://w3id.org/np/RAKBr9upCYheG0b3_xNqH20Rf5Ie7wuhounAfxr3qV5VI/quote http://www.w3.org/ns/prov#hadPrimarySource https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI:10.1038/nmat2387&resultType=core&format=json https://w3id.org/np/RAKBr9upCYheG0b3_xNqH20Rf5Ie7wuhounAfxr3qV5VI/quote http://www.w3.org/ns/prov#wasQuotedFrom https://doi.org/10.1038/nmat2387 https://w3id.org/np/RAKBr9upCYheG0b3_xNqH20Rf5Ie7wuhounAfxr3qV5VI/quote https://schema.org/text Here we discuss how advanced experimental, computational and theoretical methods can be used to assess structure-process-property relations and to monitor and predict mechanisms associated with failure of protein materials. Case studies are presented to examine failure phenomena in the progression of disease. https://w3id.org/np/RAKBr9upCYheG0b3_xNqH20Rf5Ie7wuhounAfxr3qV5VI/sourceChecksum http://spdx.org/rdf/terms#algorithm http://spdx.org/rdf/terms#checksumAlgorithm_sha256 https://w3id.org/np/RAKBr9upCYheG0b3_xNqH20Rf5Ie7wuhounAfxr3qV5VI/sourceChecksum http://spdx.org/rdf/terms#checksumValue 4d9a876f69dce0817cea95c39c5aef91659a9661a86c9ce7c4ed21685608b79d https://w3id.org/np/RAKBr9upCYheG0b3_xNqH20Rf5Ie7wuhounAfxr3qV5VI/sourceChecksum http://www.w3.org/2000/01/rdf-schema#comment Checksum of the vendored text file inputs/2009-extreme-conditions.abstract.txt, not of the publisher's copy. https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI:10.1038/nmat2387&resultType=core&format=json http://spdx.org/rdf/terms#checksum https://w3id.org/np/RAKBr9upCYheG0b3_xNqH20Rf5Ie7wuhounAfxr3qV5VI/sourceChecksum https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI:10.1038/nmat2387&resultType=core&format=json http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/ns/prov#Entity https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI:10.1038/nmat2387&resultType=core&format=json http://www.w3.org/2000/01/rdf-schema#label Abstract of Deformation and failure of protein materials in physiologically extreme conditions and disease, as read https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI:10.1038/nmat2387&resultType=core&format=json https://schema.org/about https://doi.org/10.1038/nmat2387 https://w3id.org/np/RAKBr9upCYheG0b3_xNqH20Rf5Ie7wuhounAfxr3qV5VI/pubinfo https://w3id.org/delphi/resource/domain/buehler-protein-materials http://www.w3.org/2000/01/rdf-schema#label buehler-protein-materials https://w3id.org/np/RAKBr9upCYheG0b3_xNqH20Rf5Ie7wuhounAfxr3qV5VI http://purl.org/dc/terms/created 2026-11-08T04:38:11.893Z https://w3id.org/np/RAKBr9upCYheG0b3_xNqH20Rf5Ie7wuhounAfxr3qV5VI http://purl.org/dc/terms/creator https://orcid.org/0009-0007-4948-9192 https://w3id.org/np/RAKBr9upCYheG0b3_xNqH20Rf5Ie7wuhounAfxr3qV5VI http://purl.org/dc/terms/license https://creativecommons.org/licenses/by/4.0/ https://w3id.org/np/RAKBr9upCYheG0b3_xNqH20Rf5Ie7wuhounAfxr3qV5VI http://purl.org/nanopub/x/hasNanopubType https://w3id.org/delphi/ontology/Claim https://w3id.org/np/RAKBr9upCYheG0b3_xNqH20Rf5Ie7wuhounAfxr3qV5VI http://purl.org/nanopub/x/introduces https://w3id.org/delphi/resource/claim/buehler-2009-extreme-conditions-01 https://w3id.org/np/RAKBr9upCYheG0b3_xNqH20Rf5Ie7wuhounAfxr3qV5VI http://www.w3.org/2000/01/rdf-schema#label Markus J. 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