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The ability of alpha-helix-based protein networks to withstand several hundred percent strain despite structural flaws arises from the nanomechanics of the alpha-helical constituents, which form large dissipative yield regions around flaws and so protect the network from catastrophic failure.
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Alpha-helix networks owe their flaw tolerance to large dissipative yield regions
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Theodor Ackbarow et al., “Alpha-Helical Protein Networks Are Self-Protective and Flaw-Tolerant”, PLoS ONE 4, e6015 (2009), doi:10.1371/journal.pone.0006015; Abstract. Scope: Coarse-grained (mesoscale bead) MD of a square alpha-helix network, 24 nm × 24 nm, with and without a crack
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Theodor Ackbarow, Dipanjan Sen, Christian Thaulow, Markus J. Buehler. Alpha-Helical Protein Networks Are Self-Protective and Flaw-Tolerant. PLoS ONE 4, e6015 (2009). doi:10.1371/journal.pone.0006015
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We find that the characteristic properties of alpha-helix based protein networks are due to the particular nanomechanical properties of their protein constituents, enabling the formation of large dissipative yield regions around structural flaws, effectively protecting the protein network against catastrophic failure.
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