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Assembling tropocollagen molecules into fibrils strongly reduces their bending flexibility, so entropic effects contribute less to fibril deformation than to single-molecule deformation.
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Assembly into fibrils suppresses entropic elasticity
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Markus J. Buehler et al., “Entropic Elasticity Controls Nanomechanics of Single Tropocollagen Molecules”, Biophysical Journal 93, 37-43 (2007), doi:10.1529/biophysj.106.102616; Abstract. Scope: Tropocollagen molecules versus collagen fibrils
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Markus J. Buehler, Sophie Y. Wong. Entropic Elasticity Controls Nanomechanics of Single Tropocollagen Molecules. Biophysical Journal 93, 37-43 (2007). doi:10.1529/biophysj.106.102616
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Entropic Elasticity Controls Nanomechanics of Single Tropocollagen Molecules
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We demonstrate that assembly of single tropocollagen molecules into fibrils significantly decreases their bending flexibility, leading to decreased contributions of entropic effects during deformation.
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Abstract of Entropic Elasticity Controls Nanomechanics of Single Tropocollagen Molecules, as read
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