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The repository contains no deposited memory scores for size-matched random circuits, and the ODE right-hand sides needed to generate those circuits are absent, so the comparison with 500 random circuits was not run.
https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-02--claim-test
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https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-02--claim-test
http://www.w3.org/2000/01/rdf-schema#comment
Measured: null null. Interpretation: The comparison is between two families of ODE simulations. Higher prevalence in the biological models does not show that evolved cells are more trainable than random chemistry, only that these published models, under this assay, score higher than the matched random circuits. data_kind will be computational.
https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-02--claim-test
http://www.w3.org/2000/01/rdf-schema#label
Claim test of levin-2022-grn-learning-02: inconclusive, confidence 0.35
https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-02--claim-test
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https://w3id.org/delphi/ontology/admissibleDatasets
Published ODE pathway models fetched by BioModels id, and random circuits generated from those models' sizes rather than taken from the paper's summary table. The authors' random-circuit generator is preferred when it runs.
https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-02--claim-test
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With at least 100 random circuits, the biological mean is not greater, or the one-sided p-value is at least 0.05.
https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-02--claim-test
https://w3id.org/delphi/ontology/evidenceAgainst
Random-circuit memory scores are not in the deposit, so the biological-versus-random comparison was not measured.
https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-02--claim-test
https://w3id.org/delphi/ontology/expectedObservation
Mean memory amount of the biological models is greater than that of size-matched random circuits, at one-sided p < 0.05, with at least 100 random circuits integrated.
https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-02--claim-test
https://w3id.org/delphi/ontology/failCriterion
Refutes if at least 100 random circuits integrate and (biological mean memory amount is less than or equal to the random mean, or the one-sided Mann-Whitney p is >= 0.05). Inconclusive with reason underpowered if fewer than 100 random circuits integrate. Inconclusive with reason data-unavailable if the biological models cannot be fetched.
https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-02--claim-test
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0.35
https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-02--claim-test
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https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-02--claim-test
https://w3id.org/delphi/ontology/hypothesis
Biological ODE pathway models show higher memory prevalence than size-matched random circuits.
https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-02--claim-test
https://w3id.org/delphi/ontology/inferenceMethod
One-sided Mann-Whitney U on per-model memory amount, biological versus random, alpha 0.05. Means are reported. The pre-registered direction is biological greater than random.
https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-02--claim-test
https://w3id.org/delphi/ontology/passCriterion
Pre-registered before any model file or simulation output is downloaded. The claim names 500 random circuits and a direction: biological prevalence higher than random. Memory prevalence of a model is its memory amount from the levin-2022-grn-learning-01 preregistration (fraction of tested stimulus-response pairs with at least one memory kind). Random circuits are matched to biological models on node count, with edge count matched as closely as the generator allows. The target is 500 integrated random circuits. Supports if at least 100 random circuits integrate, the mean biological memory amount is strictly greater than the mean random memory amount, and a one-sided Mann-Whitney U test (alternative: biological > random) has p < 0.05. A shortfall below 500 is recorded as a deviation and does not by itself refute. Also report, without changing the bar, whether biological mean exceeds random mean for a majority of the five memory kinds.
https://w3id.org/delphi/resource/assessment/levin-2022-grn-learning-02--claim-test
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http://purl.org/dc/terms/description
authors' MATLAB sources and deposited simulation-count matrices; the ODE right-hand sides are not in this repository
https://w3id.org/delphi/resource/evidence/levin-2022-grn-learning-02--claim-test--dataset-1
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