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delphisci dataset-resolvability assessor (Gemini 4 Argon)
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http://purl.org/dc/terms/description
The experimental variables and causal intervention (shRNA knockdown of endogenous Ang-2 under cyclic strain) are sharply defined and biologically operationalizable. However, while public transcriptomic repositories such as GEO contain expression profiles of mechanically strained HUVECs that can test mRNA up-regulation of ANGPT2 and PDGFB as a proxy, no open dataset independently archives the matched protein secretion, migration, and sprouting assays under ANGPT2 knockdown without collecting new wet-lab data.
https://w3id.org/delphi/resource/assessment/buehler-2009-angiogenesis-01--gemini
http://purl.org/dc/terms/subject
https://w3id.org/delphi/resource/concept/dataset-resolvability-0.2.0
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https://w3id.org/delphi/ontology/LLMClaimAssessment
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http://www.w3.org/2000/01/rdf-schema#comment
Proposed test with existing data: Compare secreted Ang-2 and PDGF-BB protein levels, cell migration distances, and sprout counts in HUVECs under cyclic uniaxial/biaxial tensile strain versus static controls, with and without shRNA knockdown of ANGPT2, confirming the claim if strain significantly increases all four readouts in wild-type cells and shRNA knockdown abolishes the increase.
https://w3id.org/delphi/resource/assessment/buehler-2009-angiogenesis-01--gemini
http://www.w3.org/2000/01/rdf-schema#label
Gemini 4 Argon on buehler-2009-angiogenesis-01: needs-new-data, resolvability 0.56
https://w3id.org/delphi/resource/assessment/buehler-2009-angiogenesis-01--gemini
http://www.w3.org/ns/prov#wasAttributedTo
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dataset-resolvability/0.2.0
https://w3id.org/delphi/resource/assessment/buehler-2009-angiogenesis-01--gemini
https://w3id.org/delphi/ontology/evidenceAgainst
Mechanical strain protocols in public datasets vary widely in frequency, amplitude, substrate coating, and duration.
https://w3id.org/delphi/resource/assessment/buehler-2009-angiogenesis-01--gemini
https://w3id.org/delphi/ontology/evidenceAgainst
Public GEO datasets provide transcriptomic profiles of stretched HUVECs rather than the combined ELISA protein secretion, shRNA ANGPT2 knockdown, and 3D sprouting assay readouts required by the claim.
https://w3id.org/delphi/resource/assessment/buehler-2009-angiogenesis-01--gemini
https://w3id.org/delphi/ontology/hasConfidence
0.8
https://w3id.org/delphi/resource/assessment/buehler-2009-angiogenesis-01--gemini
https://w3id.org/delphi/ontology/hasEvidence
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https://w3id.org/delphi/ontology/hasEvidence
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https://w3id.org/delphi/ontology/hasScore
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https://w3id.org/delphi/ontology/hasVerdict
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Analysis feasibility of buehler-2009-angiogenesis-01 by Gemini 4 Argon: 0.55
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Data adequacy of buehler-2009-angiogenesis-01 by Gemini 4 Argon: 0.3
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Data existence of buehler-2009-angiogenesis-01 by Gemini 4 Argon: 0.4
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0.85
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https://w3id.org/delphi/resource/evidence/buehler-2009-angiogenesis-01--gemini--dataset-1
http://purl.org/dc/terms/description
Public transcriptomic datasets of mechanically stretched or shear-stressed human umbilical vein endothelial cells to check ANGPT2 and PDGFB mRNA up-regulation
https://w3id.org/delphi/resource/evidence/buehler-2009-angiogenesis-01--gemini--dataset-1
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
https://w3id.org/delphi/ontology/EvidenceItem
https://w3id.org/delphi/resource/evidence/buehler-2009-angiogenesis-01--gemini--dataset-1
http://www.w3.org/2000/01/rdf-schema#label
Candidate dataset: NCBI Gene Expression Omnibus
https://w3id.org/delphi/resource/evidence/buehler-2009-angiogenesis-01--gemini--dataset-1
http://www.w3.org/ns/prov#wasDerivedFrom
https://www.ncbi.nlm.nih.gov/geo/
https://w3id.org/delphi/resource/evidence/buehler-2009-angiogenesis-01--gemini--dataset-2
http://purl.org/dc/terms/description
Curated human Tie2/Angiopoietin and PDGF signaling pathways in endothelial sprouting
https://w3id.org/delphi/resource/evidence/buehler-2009-angiogenesis-01--gemini--dataset-2
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
https://w3id.org/delphi/ontology/EvidenceItem
https://w3id.org/delphi/resource/evidence/buehler-2009-angiogenesis-01--gemini--dataset-2
http://www.w3.org/2000/01/rdf-schema#label
Candidate dataset: Reactome Pathway Knowledgebase
https://w3id.org/delphi/resource/evidence/buehler-2009-angiogenesis-01--gemini--dataset-2
http://www.w3.org/ns/prov#wasDerivedFrom
https://reactome.org/
https://w3id.org/delphi/resource/model/gemini-4-argon-medium
http://purl.org/dc/terms/identifier
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http://www.w3.org/2000/01/rdf-schema#label
Gemini 4 Argon
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https://w3id.org/delphi/resource/agent/delphisci-resolvability-assessor-gemini-4-argon-medium
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http://www.w3.org/ns/prov#wasDerivedFrom
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http://www.w3.org/ns/prov#wasDerivedFrom
https://w3id.org/delphi/resource/concept/dataset-resolvability-0.2.0
https://w3id.org/np/RA-z1sg0aVt2aobGfmz1cB6peVFIqQGl7M4qHKiEmNrRk/assertion
http://www.w3.org/ns/prov#wasGeneratedBy
https://w3id.org/np/RA-z1sg0aVt2aobGfmz1cB6peVFIqQGl7M4qHKiEmNrRk/assessment
https://w3id.org/np/RA-z1sg0aVt2aobGfmz1cB6peVFIqQGl7M4qHKiEmNrRk/assessment
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http://www.w3.org/ns/prov#Activity
https://w3id.org/np/RA-z1sg0aVt2aobGfmz1cB6peVFIqQGl7M4qHKiEmNrRk/assessment
http://www.w3.org/ns/prov#qualifiedAssociation
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https://w3id.org/delphi/resource/agent/delphisci-resolvability-assessor-gemini-4-argon-medium
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https://github.com/fractastical/delphisci/blob/67fe5b156cfeca15a2ded33e0face4177d03101c/claim-sources/buehler-protein-materials/README.md
https://w3id.org/np/RA-z1sg0aVt2aobGfmz1cB6peVFIqQGl7M4qHKiEmNrRk/pubinfo
https://w3id.org/delphi/resource/domain/buehler-protein-materials
http://www.w3.org/2000/01/rdf-schema#label
buehler-protein-materials
https://w3id.org/np/RA-z1sg0aVt2aobGfmz1cB6peVFIqQGl7M4qHKiEmNrRk
http://purl.org/dc/terms/created
2026-11-08T04:48:50.317Z
https://w3id.org/np/RA-z1sg0aVt2aobGfmz1cB6peVFIqQGl7M4qHKiEmNrRk
http://purl.org/dc/terms/creator
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http://purl.org/dc/terms/license
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http://purl.org/nanopub/x/hasNanopubType
https://w3id.org/delphi/ontology/LLMClaimAssessment
https://w3id.org/np/RA-z1sg0aVt2aobGfmz1cB6peVFIqQGl7M4qHKiEmNrRk
http://purl.org/nanopub/x/introduces
https://w3id.org/delphi/resource/assessment/buehler-2009-angiogenesis-01--gemini
https://w3id.org/np/RA-z1sg0aVt2aobGfmz1cB6peVFIqQGl7M4qHKiEmNrRk
http://www.w3.org/2000/01/rdf-schema#label
Gemini 4 Argon on buehler-2009-angiogenesis-01: needs-new-data, resolvability 0.56
https://w3id.org/np/RA-z1sg0aVt2aobGfmz1cB6peVFIqQGl7M4qHKiEmNrRk
https://w3id.org/delphi/ontology/domain
https://w3id.org/delphi/resource/domain/buehler-protein-materials
https://w3id.org/np/RA-z1sg0aVt2aobGfmz1cB6peVFIqQGl7M4qHKiEmNrRk/sig
http://purl.org/nanopub/x/hasAlgorithm
RSA
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http://purl.org/nanopub/x/hasPublicKey
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https://w3id.org/np/RA-z1sg0aVt2aobGfmz1cB6peVFIqQGl7M4qHKiEmNrRk/sig
http://purl.org/nanopub/x/hasSignature
G01qUK/eop75/u+ZoI0gYOXjgbVUDITg5H6HbTH6gHORK4OCaMQ+KUuIEuAVYoVT2TUPM5K4WzwqSKdvG7p/7F3nySm3mQm2C/RscoMujYm2s2Mdg3I0h7zro04wGPpPiv2vj1s4LdWAbEqEyigl1WoHyg6qdo61hvsxx1QD+wRQZX1HVmOnh70sBWS5yidUxsWgpkF88d7LIomjMseH6FJieh7rULr99Io267kjcvganzRKRneiNm+SsJS9czCRXuLe9+NcfaB6mOHbz1aRBeNidaC8xZETHGchWgtL7EE1UfdMOpaPLmHYeyiFbV5crk/gsCbiOwxuR9rK1pXCTw==
https://w3id.org/np/RA-z1sg0aVt2aobGfmz1cB6peVFIqQGl7M4qHKiEmNrRk/sig
http://purl.org/nanopub/x/hasSignatureTarget
https://w3id.org/np/RA-z1sg0aVt2aobGfmz1cB6peVFIqQGl7M4qHKiEmNrRk
https://w3id.org/np/RA-z1sg0aVt2aobGfmz1cB6peVFIqQGl7M4qHKiEmNrRk/sig
http://purl.org/nanopub/x/signedBy
https://orcid.org/0009-0007-4948-9192